Deazaalloxazines - Flavin Derivatives That Provide Reductive Photoredox Catalysis with Inert Substrates.

ABSTRACT: Reductive transformations of substances that are difficult to reduce continue to pose challenges for photoredox catalysis. Promising photoreduction catalysts include flavin and deazaflavin derivatives; however, even their reductive abilities are limited for the range of substrates considered "inert". In this work, we present 5-deazaalloxazines, a new group of deazaflavin analogues that are predisposed to catalyze reductions due to their low reduction potential (down to -1.65 V vs. SCE) even in the ground state. We studied three series of 5-deazaalloxazines ([i] 5-unsubstituted, [ii] 5-aryldeazaalloxazines, and [iii] 5-trifluoromethyl-5-deazaalloxazines) to determine their photophysical and electrochemical properties and their ability to participate in model photoreduction reactions. From 3

SUBMITTER: Weisheitelova I 

PROVIDER: S-EPMC12734692 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature