Phenotypic Remodeling of γδ T Cells in Non-Eosinophilic Chronic Rhinosinusitis with Nasal Polyposis.

ABSTRACT: Background and Objectives: Emerging evidence indicates that γδ T cells contribute to mucosal inflammation, yet their composition and functional characteristics in the nasal mucosa and nasal polyps remain insufficiently defined. This study aimed to characterize γδ T cell subsets in patients with non-eosinophilic chronic rhinosinusitis with nasal polyps (non-ECRSwNP) and to assess their associations with clinical features. Materials and Methods: Using flow cytometry, we analyzed the frequencies and phenotypes of γδ T cell subsets in middle nasal turbinate (MNT) tissue and nasal polyps from patients with non-eosinophilic chronic rhinosinusitis with nasal polyps (non-ECRSwNP), and compared them with nasal mucosa from healthy controls. Correlations with age, sex, disease severity,

SUBMITTER: Bogovic V 

PROVIDER: S-EPMC12734732 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature