Validation of the Controlling Nutritional Status (CONUT) Score and the Systemic Immune-Inflammation Index (SII) for Predicting Leakage and Surgical Complications After Head and Neck Free Flap Reconstruction: A Pilot Study.

ABSTRACT: Background and Objectives: While many factors are known to influence adverse outcomes after head and neck cancer ablation with free flap reconstruction, two low-cost inflammatory-nutritional indices-the Controlling Nutritional Status (CONUT) score and the Systemic Immune-Inflammation Index (SII)-are not widely used. This pilot study evaluated their accuracy for predicting surgical complications, including flap-site leakage, and explored data-driven cutoff values. Materials and Methods: We retrospectively analyzed 115 consecutive patients undergoing free-flap reconstruction. Data from medical records were obtained. Preoperative CONUT and SII were computed, receiver-operating characteristic (ROC) curves derived optimal thresholds, and associations with outcomes were tested usin

SUBMITTER: Lee JW 

PROVIDER: S-EPMC12734734 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature