Zinc-Related Proteasome Variants in Type 1 Diabetes: An in Silico-Guided Case-Control Study.

ABSTRACT:

Introduction

The proteasome is a multicatalytic complex responsible for protein degradation and regulation of immune responses, and has been implicated in type 1 diabetes mellitus (T1DM) pathogenesis. Zinc (Zn²⁺) is essential for insulin granule biogenesis and modulates proteasomal activity. This study investigated associations between single-nucleotide polymorphisms (SNPs) in proteasomal subunits predicted to bind Zn²⁺ and T1DM susceptibility or related traits.

Methods

This case-control study included 654 patients with T1DM and 573 subjects without DM from Southern Brazil. SNPs were selected through in silico analysis using MIB docking platform to identify Zn²⁺-interacting residues in proteasomal subunits. Five SNPs in proteasomal subunit ge

SUBMITTER: Nasre-Nasser RG 

PROVIDER: S-EPMC12734831 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature