The Discovery of Antibacterial Cembranoids from the Soft Coral <i>Lobophytum crassum</i> by DeepSAT Analysis.

ABSTRACT: Eight previously unreported cembranoids (1-8), along with four known ones (9-12), have been isolated and identified from the soft coral Lobophytum crissum collected from the South China Sea under the guidance of HSQC-based DeepSAT analysis for targeted isolation. The structures of the new compounds were determined by comprehensive spectroscopic analysis, QM-NMR, TDDFT-ECD calculations, and comparison with reported literature data from analogs. In in vitro bioassays, all the isolated compounds have been screened for their antibacterial and antiproliferative activities.

SUBMITTER: Wu B 

PROVIDER: S-EPMC12734846 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature