When Conventional Methods Fail: First Detection of a <i>Candida viswanathii</i> Outbreak in Europe in a Pediatric Hospital Revealed by Whole Genome Sequencing and FT-IR Spectroscopy.

ABSTRACT: Candida viswanathii has been sporadically reported in Asia and South America but not in Europe. This study reports the first European outbreak of C. viswanathii in a paediatric hospital, outlining diagnostic challenges and containment measures. Fifteen C. viswanathii isolates were recovered from blood cultures of consecutive pediatric patients admitted to intensive care units between April and August 2025. Identification was performed using MALDI-TOF MS, chromogenic media, Fourier-transform infrared (FT-IR) spectroscopy, and whole-genome sequencing (WGS). Antifungal susceptibility testing was performed by broth microdilution. All isolates were initially misidentified as C. tropicalis by MALDI-TOF MS and undetected by the FilmArray BCID2 panel. WGS confirmed C

SUBMITTER: Vrenna G 

PROVIDER: S-EPMC12734905 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature