Biofabrication of <i>Terminalia ferdinandiana</i>-Conjugated Gold Nanoparticles and Their Anticancer Properties.

ABSTRACT: Harnessing nature's chemistry, this study explores the enhanced biomedical potential of Terminalia ferdinandiana Exell (Kakadu Plum) by transforming its aqueous leaf and fruit extracts into bio-inspired gold nanoparticles (AuNPs). The synthesis process was optimized by varying the Au³⁺/extract ratio and pH, with nanoparticle formation verified through UV-visible spectrophotometry, TEM, and DLS analyzes. Kakadu Leaf extract-conjugated AuNPs (AuKLs), synthesized at pH 8 with a 1:25 Au³⁺/extract ratio, produced the smallest and most uniform particles (21.1 nm; PDI 0.17). In contrast, fruit extract alone failed to generate stable nanoparticles, highlighting the pivotal role of leaf phytochemicals as natural reducing and stabilizing agents. Biological evaluations re

SUBMITTER: Alwis WHS 

PROVIDER: S-EPMC12734994 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature