Hyperleptinemia Is a Risk Factor for the Development of Vascular Reactivity Impairment in Patients with Hypertension.

ABSTRACT: Background and Objectives: Endothelial dysfunction represents an early indicator of cardiovascular disease in individuals with hypertension. Leptin, an adipokine that regulates vascular homeostasis and metabolism, has been linked to vascular impairment; however, its relationship with vascular reactivity in hypertensive patients remains unclear. Materials and Methods: A cross-sectional study was conducted involving 100 hypertensive patients recruited from the cardiovascular outpatient clinic of Hualien Tzu Chi Hospital between January and July 2021. Clinical profiles, anthropometric data, and laboratory results were collected. Endothelial function was evaluated through digital thermal monitoring, with vascular reactivity index (VRI) classified as poor (<1.0), intermediate (1.0

SUBMITTER: Su IM 

PROVIDER: S-EPMC12735040 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature