Genomic Scan for Runs of Homozygosity and Identification of Candidate Genes Under Domestication in Fengjing Pigs.

ABSTRACT: Fengjing pigs are a Chinese native breed known for their high reproductive ability. Runs of homozygosity (ROHs) have emerged as an effective tool for evaluating inbreeding levels and identifying relevant genes in selection. However, the declining population of Fengjing pigs in recent years has raised concerns about inbreeding. Therefore, this study aimed to investigate the ROH patterns, estimate genomic inbreeding levels, and identify candidate genes associated with economic traits using whole-genome resequencing data from 105 Fengjing pigs. A total of 2448 ROHs were identified, with an average of 23.31 ROHs per individual and an average length of 9.50 Mb. The inbreeding coefficient, based on ROHs, was 0.098. Additionally, three genomic regions with a high frequency of ROHs were identified

SUBMITTER: Ni L 

PROVIDER: S-EPMC12735110 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature