<i>FADS1</i> and <i>FADS2</i> Gene Polymorphisms Affect Omega-3 and Omega-6 Erythrocyte Fatty Acid Composition and Influence the Association Between Dietary Fatty Acid Intake and Lipid Profile in Brazilian Adults.

ABSTRACT: Background: Polymorphisms in the FADS1 and FADS2 genes influence fatty acid metabolism. However, evidence of gene-diet interactions in population-based studies from Brazil remains limited. The objective of this study was to examine associations between FADS1-FADS2 single-nucleotide polymorphisms (SNPs) and erythrocyte fatty acid composition and serum lipid concentrations, as well as to explore potential gene-diet interactions. Methods: Data were analyzed from 294 adults (20-93 years) enrolled in the 2015 ISA-Nutrition study. Erythrocyte fatty acid composition and serum lipids were measured using standard enzymatic methods. Dietary intake was assessed by 24 h recalls, and participants were classified into tertiles according to fatty acid intake. Five SNPs

SUBMITTER: Batista LD 

PROVIDER: S-EPMC12735183 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature