Differential Effects of Assisted Reproduction Technology on Placental Epigenetics and Angiogenesis: Insights from Fresh, Frozen, and Egg Donation Pregnancies.

ABSTRACT: Background: The placenta plays a fundamental role in supporting fetal development, with angiogenesis being crucial for establishing an efficient maternal-fetal interface. Epigenetic mechanisms, particularly DNA methylation, can regulate the expression of angiogenesis-related genes and may be influenced by Assisted Reproductive Technology (ART), including In Vitro Fertilization (IVF) with fresh or frozen-thawed embryo transfer (ET and FET, respectively) and egg donation (ED), all potentially affecting placental vascular development and pregnancy outcomes. The present study compared global DNA methylation levels and the expression of Vascular Endothelial Growth Factor (VEGF), Placental Growth Factor (PlGF), and Soluble Fms-Like Tyrosine kinase-1 (sFlt-1) in placentae from physi

SUBMITTER: Nuzzo AM 

PROVIDER: S-EPMC12735257 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature