Metabolic Shifts Induced by Treatment with Statin Influences Circulating Concentrations of the Stress Hormone, Cortisol, but Has Different Effects on Selected Cytokines, Adipokines and Neuropeptides in Lean and Fat Lines of Young Pigs.

ABSTRACT: Background: It was hypothesized that short statin treatment would shift adipose expression, plasma and adipose tissue concentrations of adipokines and cytokines. Methods: Effects of a statin administration on adipokines (leptin, resistin and visfatin), adipose inflammatory cytokines [interleukin-6 (IL-6) and tumor necrosis factorα (TNFα)] were examined in young pigs of both lean and fat breeds. Results: Expression of resistin was increased while that of visfatin was decreased in visceral adipose tissue and, to a lesser extent, in epicardial adipose tissue. In young pigs treated with statin, there were increases in the plasma concentrations of leptin, resistin and TNFα. There were also decreases in the plasma concentrations of visfatin, cortisol, Met-enkephalin and endo

SUBMITTER: Pierzchala-Koziec K 

PROVIDER: S-EPMC12735346 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature