Enhanced Toxicity of Diol-Estered Diarrhetic Shellfish Toxins Across Trophic Levels: Evidence from <i>Caenorhabditis elegans</i> and <i>Mytilus galloprovincialis</i>.

ABSTRACT: Prorocentrum lima is a widely distributed and major source of diarrhetic shellfish toxins (DSTs); the ecological impact of diol-estered DSTs (eDSTs) compounds on benthic systems is still inadequate. In this study, the acute toxicity of eDSTs was evaluated in Caenorhabditis elegans, and their accumulation capacity and toxic effects were examined in Mytilus galloprovincialis for an ecological risk assessment. The results indicated that larvae 1 (L1) was more sensitive than larvae 4 (L4) of C. elegans, and the eDSTs in P. lima extract lysate were more toxic than the okadaic acid (OA) standard solution. The lowest LC₅₀ values were 0.293 and 0.469 μg/mL for L1 and L4, respectively. The growth, productivity, and intestinal permeability of C. elega

SUBMITTER: Chen C 

PROVIDER: S-EPMC12735357 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature