Estrogen-Dependent Variation in the Contributions of TRPM4 and TRPM5 to Fat Taste.

ABSTRACT:

Background

Sex differences in physiology have garnered significant interest of late; however, comparatively little is known about the effects of sex on the function of the peripheral taste system. Previously, we have shown that fat taste functions in a sexually dimorphic manner using molecular, cellular, and behavioral assays, and that a subtype of estrogen receptor (ER) proteins is highly expressed in Type II (receptor) cells. The underlying mechanisms of estrogen's action, though, remain unknown.

Objective

Here, we sought to better understand estrogen's role in fat taste transduction at the molecular level by initially focusing on the transient receptor potential channel types M4 (Trpm4) and M5 (Trpm5), which we have shown to play roles in estrogen-sensitive

SUBMITTER: Masterson E 

PROVIDER: S-EPMC12735415 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature