New Insights into Synergistic Boosts in SCFA Production Across Health Conditions Induced by a Fiber Mixture.

ABSTRACT: Background/Objectives: Short-chain fatty acids (SCFAs) produced by gut microbiota from dietary fiber fermentation play crucial roles in health and disease. While most research focuses on individual fibers, this study investigated whether a fiber mixture could synergistically increase SCFAs, exceeding the expected average production of individual contributions and microbial signatures associated with this phenomenon. Methods: We quantified synergistic SCFA production using secondary analysis of in vitro fecal fermentation data from 33 participants across four health conditions (healthy controls, Crohn's disease, ulcerative colitis, and Parkinson's disease), by comparing observed fiber mixture output to expected additive contributions from individual components and identified m

SUBMITTER: Galeano-Garcia GS 

PROVIDER: S-EPMC12735490 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature