<i>Leishmaniavirus</i> Type 1 Enhances In Vitro Infectivity and Modulates the Immune Response to <i>Leishmania (Viannia)</i> Isolates.

ABSTRACT: Leishmania RNA virus 1 (LRV-1) is a double-stranded RNA virus identified in several Leishmania spp. LRV-1 has been associated with increased disease severity and therapeutic failure in cutaneous leishmaniasis (CL). Although LRV-1 has been reported in the Americas, its influence on parasite infectivity and host immune responses remains poorly characterized in Panamanian isolates. In this study, we investigate the in vitro infectivity and immunomodulatory effects of LRV-1-positive (LRV-1⁺) versus LRV-1-negative (LRV-1^-) isolates of Leishmania (Viannia), including clinical strains of L. (V.) panamensis and L. (V.) guyanensis. A total of 21 isolates (nine LRV-1⁺, nine

SUBMITTER: Bonilla Fong AA 

PROVIDER: S-EPMC12735641 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature