Identification and Quantitation of ¹⁴C-Labeled Catechol Metabolites in Rat Plasma After Intranasal Instillation of Smoldering Eucalyptus Wood Smoke Extract.

ABSTRACT: The increasing frequency, duration, and intensity of wildfires over the past decade have raised significant concerns about widespread exposure to wildfire smoke. Inhalation of wildfire smoke poses a substantial risk to human health, with epidemiological studies linking exposure to cardiovascular, respiratory, and neurological dysfunction. Wildfire smoke contains hundreds of chemical compounds across diverse classes, with concentrations varying by fuel type and combustion conditions. Phenolic compounds are prominent constituents of wood smoke, and catechol is especially abundant under smoldering conditions that produce dense smoke. In this study, ¹⁴C-labeled catechol was spiked into smoldering eucalyptus wood smoke extract (WSE) and administered to rats via intranasal instillatio

SUBMITTER: Baliu-Rodriguez D 

PROVIDER: S-EPMC12735648 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature