Interference of <i>Pseudomonas aeruginosa</i> Virulence Factors by Different Extracts from <i>Inula</i> Species.

ABSTRACT: Objectives: Pseudomonas aeruginosa is an opportunistic pathogen of high clinical relevance due to its ability to form biofilms, its inherent virulence regulated by quorum-sensing systems, and its multidrug resistance. In the present study, we evaluated the inhibitory potential of nine extracts from Inula species (chloroform and methanolic fractions, including a sesquiterpene lactone-enriched fraction) against biofilm formation and virulence-associated traits of P. aeruginosa PAO1 and three multidrug-resistant clinical isolates, as well as their cytotoxicity, biocompatibility, and ability to affect cytokine and nitric oxide production in infected skin explants. Methods: The following methods were applied: fractionation and extraction of plant extracts; cytotoxici

SUBMITTER: Paunova-Krasteva T 

PROVIDER: S-EPMC12735715 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature