Organ-Specific Distribution of Antimycobacterial Neolignans in <i>Piper rivinoides</i> and UHPLC-HRMS/MS Analysis of Its Extracts.

ABSTRACT: This multidisciplinary study investigates Piper rivinoides, a Brazilian medicinal species, focusing on its chemical composition and antimycobacterial potential. UHPLC-HRMS/MS of leaves, stems, branches, and roots revealed 58 compounds, including neolignans, lignanamides, triterpenes, flavonoids, and carotenoids. Fourteen metabolites, notably benzofuran neolignans and pentacyclic triterpenes are annotated here for the first time. Quantitative analyses by HPLC-DAD-UV showed that eupomatenoid-5, eupomatenoid-6, and conocarpan were most abundant in leaves, reaching amounts approximately twice those found in branches and stems and about ten times higher than in roots, supporting the optimal defense theory and organ-specific accumulation of bioactive metabolites. Biological assays against

SUBMITTER: Felisberto JS 

PROVIDER: S-EPMC12735719 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature