Bromo Analogues of Active 3,4,5,4'-Tetramethoxy-<i>trans</i>-stilbene (DMU-212)-A New Path of Research to Anticancer Agents.

ABSTRACT: Stilbenes are a group of polyphenols that are gaining steady attention and have promising biological activity. While much attention is given to polyhydroxy compounds derived from resveratrol, other substituents remain largely unexplored. In this work, we present the results of studies on the synthesis, physicochemical characterisation, and ADME parameters simulation of polymethoxy and brominated stilbenes. We also examined their anticancer activity and found that some of the brominated compounds reveal desirable properties. While the brominated derivatives are not significantly more active than the polymethoxy derivatives, they were found to be safer for the tested pseudo-normal cell lines.

SUBMITTER: Lazewski D 

PROVIDER: S-EPMC12735739 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature