Complete Genome Sequence Analysis and Probiotic Characterisation of <i>Lactiplantibacillus plantarum</i> Y300 Isolated from Traditional Free-Range Chickens.

ABSTRACT: As a core strategy for antibiotic replacement, probiotics have two advantages insofar as they enhance both animal productivity and pathogen suppression. In this study, we screened the intestines of antibiotic-naïve chickens for broad-spectrum antimicrobial lactic acid bacteria (LAB) with natural adaptability, based on the host-microbiota coevolution theory, and systematically evaluated their potential for development as poultry probiotics. We isolated a LAB strain, Lactiplantibacillus plantarum Y300, from traditional native free-range chickens, which showed strong inhibitory activity against avian pathogenic Salmonella, Escherichia coli, and Staphylococcus aureus. In vitro experiments indicated that the Lpb. plantarum strain Y300 had no hemolytic activity

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12735756 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature