The Role of Vitamin D in Parkinson's Disease: Evidence from Serum Concentrations, Supplementation, and <i>VDR</i> Gene Polymorphisms.

ABSTRACT:

Background/aim

Vitamin D (VitD) has been implicated in neuroprotection, yet its role in Parkinson's disease (PD) remains unclear. This systematic review and meta-analysis aimed to evaluate the association between VitD status, supplementation, and vitamin D receptor (VDR) gene polymorphisms with PD risk and outcomes.

Methodology

Following PRISMA guidelines, we searched PubMed, Scopus, and Google Scholar through August 2025 for observational studies, clinical trials, and genetic association studies. Primary outcomes included serum VitD levels in PD versus healthy controls (HCs), prevalence of VitD insufficiency/deficiency, and effects of VitD supplementation on motor symptoms. Secondary outcomes assessed associations between VDR polymorphisms and PD susceptibilit

SUBMITTER: Rissardo JP 

PROVIDER: S-EPMC12735780 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature