Characterisation of a Novel <i>Pseudomonas</i> Phage and Its Effect on the Survival of <i>Galleria mellonella</i> Larvae.

ABSTRACT: Multi-drug-resistant Pseudomonas aeruginosa (P. aeruginosa) commonly causes infections that are difficult to treat, necessitating the development of new therapeutics. The search for more effective ways to combat the emergence of bacterial resistance has also led to research into phage-antibiotic synergy (PAS) as a potential therapeutic strategy. The aim of this study was to isolate and characterize virulent phages from water sources that are active against clinical carbapenem-resistant P. aeruginosa isolates, and to evaluate their in vivo efficacy using a Galleria mellonella larvae infection model. The biological and genomic characteristics of the isolated phages were determined using host range analysis, one-step growth curve analysis, transmission electron mic

SUBMITTER: Ozturk S 

PROVIDER: S-EPMC12735786 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature