IL-10 Plays a Critical Role in Mitigating Acute Anaemia Development During African Trypanosome Infection.

ABSTRACT: During the first week of T. b. brucei infection, pro-inflammatory IFN-γ production drives acute anaemia by promoting red blood cell clearance by activated macrophages in concert with insufficient bone marrow compensation. The latter is followed by a partial recovery phase, which later progresses to chronic anaemia. To compensate for acute anaemia, stress-induced extramedullary erythropoiesis occurs in the spleen. However, the role of IL-10, a key anti-inflammatory cytokine in regulating stress-induced acute anaemia during African trypanosomosis (AT), remains unclear. Using both genetic and pharmacological approaches, we show that IL-10 is essential to limit acute anaemia by dampening inflammation and promoting splenic erythropoiesis, enabling recovery. More specifically, IL-10 block

SUBMITTER: Zivalj M 

PROVIDER: S-EPMC12735828 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature