Polymeric Nanoparticles with Surface-Anchored Functional Groups as Chelating Agents for Calcium (Ca²⁺) and Magnesium (Mg²⁺) Ions to Inhibit Cellular Interactions.

ABSTRACT: Background: Cancer therapeutics development has been a challenge in medical and scientific areas due to their toxicity, limited biocompatibility, and unfortunate side effects. However, despite advances in early detection and the study of novel treatments, the mortality rate for breast cancer remains high, making it a significant global health concern. Objectives: In this study, poly(methyl methacrylate) (PMMA) nanoparticles functionalized with acrylic acid (AA), fumaramide (FA), and curcumin (CUR) as chelating and inhibitor agents were synthesized by emulsion polymerization techniques. Methods and Results: Comprehensive physiochemical characterization studies based on gravimetry, dynamic light scattering (DLS), electrophoresis, Fourier transform infrared (FT-IR), ultra

SUBMITTER: Ruiz-Virgen L 

PROVIDER: S-EPMC12735866 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature