Modulation of Dextran Sodium Sulfate-Induced Colitis in Germ-Free Mice by <i>Enterococcus faecalis</i> Monocolonization.

ABSTRACT: Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis (UC), are characterized by chronic gastrointestinal inflammation and involve complex interactions of genetic, environmental, and immune factors. Enterococcus faecalis, a gut commensal bacterium, has been implicated in IBD pathogenesis. This study investigated the effects of monocolonization with a UC-derived E. faecalis strain on acute dextran sulfate sodium (DSS)-induced colitis in germ-free (GF) mice, focusing on epithelial injury, inflammatory markers, hematologic indices, and bacterial translocation. In DSS-treated mice, monocolonization was associated with modest and mixed effects, including a higher colitis-related disease activity score, reduced anemia, increased fecal albumin and a tr

SUBMITTER: Vestad B 

PROVIDER: S-EPMC12735899 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature