The Gut Microbiome in Stevens-Johnson Syndrome and Sjogren's Disease: Correlations with Dry Eye.

ABSTRACT: Changes in gut microbial composition may influence mucosal immune responses and contribute to systemic autoimmune manifestations. In this pilot exploratory study, we investigated and compared the gut microbiome in patients with Stevens-Johnson syndrome (SJS), patients with Sjögren's disease (SjD), and healthy controls, using next-generation sequencing (NGS), and assessed correlations with dry eye parameters. The study included 10 patients with SJS matched by age and sex to 10 healthy controls, and 10 patients with SjD matched to an additional set of 10 healthy controls. Dry eye parameters were employed to evaluate dry eye disease (DED). Microbiome profiles were determined using next-generation sequencing of the 16S V3-V4 region and analyzed using the Silva database. The gut microbiome exhi

SUBMITTER: Frizon L 

PROVIDER: S-EPMC12735903 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature