Yerba Mate (<i>Ilex paraguariensis</i>) and Rheumatoid Arthritis: A Systematic Review of Mechanistic and Clinical Evidence.

ABSTRACT: Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease driven by persistent inflammation and oxidative stress. Ilex paraguariensis (yerba mate) contains bioactive compounds-particularly chlorogenic acids, quercetin, and rutin-with documented antioxidant and anti-inflammatory properties. Objectives: To systematically review the mechanistic and clinical evidence on Ilex paraguariensis and its main constituents in RA-relevant inflammatory, oxidative, and bone metabolic pathways. Methods: Following PRISMA 2020, PubMed/MEDLINE, LILACS, and SciELO were searched up to September 2025. Eligible studies included yerba mate preparations (last 10 years) or isolated compounds (last 5 years) assessing RA-relevant clinical, inflammatory, oxidative, or bon

SUBMITTER: Cassotta M 

PROVIDER: S-EPMC12735931 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature