Regulation of NAD⁺ Homeostasis by <i>Ss</i>NrtR in <i>Streptococcus Sobrinus</i>: A Critical Determinant of Its Cariogenic Potential.

ABSTRACT: Nicotinamide adenine dinucleotide (NAD⁺) serves as a critical cofactor in redox reactions and metabolic transformations catalyzed by NAD-dependent enzymes and is essential for bacterial survival and virulence. The biosynthesis of NAD⁺ in the cariogenic pathogen Streptococcus Sobrinus (S. sobrinus), a pivotal participant in oral cavities of children and adolescents with a history of caries, has yet to be explored. Bioinformatics, genetics, and biochemical techniques were used to identify NAD⁺ biosynthesis pathways and corresponding regulator in S. Sobrinus. S. sobrinus lacks de novo NAD⁺ synthesis pathway but comprises NA and Nam salvage pathway I (PncA-PncB-NadD-NadE) and PnuC-NadR salvage pathway III. NiaY and PnuC we

SUBMITTER: Lv S 

PROVIDER: S-EPMC12735969 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature