Integrative Multi-Omics Analysis of the Rumen in <i>Tan</i> Sheep with Contrasting Average Daily Gain.

ABSTRACT: Understanding the drivers of average daily gain (ADG) is key to enhancing the productivity of Tan sheep. This study employed an integrated multi-omics approach to compare rumen microbial communities (16S rRNA sequencing) and metabolomic profiles between Tan sheep with high (HADG) and low (LADG) ADG. The novelty of this work lies in the systems-level identification of functional linkages between specific rumen bacteria and metabolites that underlie divergent growth phenotypes. The results revealed no significant difference in initial body weight between the two groups (p > 0.05). However, the HADG group showed significantly higher final body weight (p < 0.05), markedly greater ADG and Average Daily Dry Matter Intake (ADFI) (p < 0.01), and a substantially l

SUBMITTER: Zheng H 

PROVIDER: S-EPMC12736088 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature