Alterations in Gut Microbial Co-Abundance Networks in Metabolic Syndrome: A Population-Based Cross-Sectional Study.

ABSTRACT: Metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular diseases and type 2 diabetes. Gut microbiota dysbiosis has been implicated in the pathogenesis of MetS, but the mechanisms remain poorly understood. This study investigates gut microbiota interaction networks in MetS and explores their potential role in host metabolic regulation. In this population-based cross-sectional study, 221 MetS patients and 382 healthy controls were analyzed. Co-abundance network analysis was used to examine microbial interactions across the study. Significant differences in microbial co-abundance patterns were observed between MetS and healthy participants. In MetS, the gut microbiota displayed fewer and generally weaker co-abundance correlations compared with healthy controls. These changes

SUBMITTER: Fang Y 

PROVIDER: S-EPMC12736139 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature