Systematic Review: Proteomics-Driven Multi-Omics Integration for Alzheimer's Disease Pathology and Precision Medicine.

ABSTRACT:

Background

Neurodegenerative diseases remain a central topic in biomedical research, with Alzheimer's disease (AD) being the most extensively studied. Recent advances in multi-omics integration, particularly proteomics-based approaches, have enabled a deeper understanding of AD-related molecular pathways and their interconnections. However, challenges such as data heterogeneity and the complexity of large-scale datasets continue to hinder comprehensive integration and model interpretation.

Methods

A total of 792 publications were retrieved from PubMed, among which, 27 peer-reviewed studies from 2024 and 2025 focusing on proteomics-anchored multi-omics integration for AD were selected for detailed analysis. These papers were categorized based on their integration strategies,

SUBMITTER: Dong JM 

PROVIDER: S-EPMC12736289 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature