Inulin Reverses Intestinal Mrp2 Downregulation in a Diet-Induced Obesity Mouse Model: Role of Intestinal Microbiota as a Pivotal Modulator.

ABSTRACT: Background: The intestinal microbiota (IM) modulates host physiology, and its alteration (dysbiosis) is associated with numerous diseases, including obesity. This condition influences the pharmacokinetics of drugs prescribed for related comorbidities, although the underlying mechanisms remain poorly understood. Mrp2, an essential ABC transporter of the intestinal biochemical barrier, regulates the absorption of dietary toxins and orally administered drugs, modulating their bioavailability. However, its regulation in the obesity context is poorly characterized, and the role of IM alteration in this process remains unknown. Objective: To evaluate the role of the IM as a key factor, along with downstream candidate mediators, in the regulation of Mrp2 under obesity conditions.

SUBMITTER: Zecchinati F 

PROVIDER: S-EPMC12736295 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature