Curcumin and Resveratrol vs. Ferrocene-Modified Polyphenols: Role in Enhancing Protective Properties in Human Keratinocytes.

ABSTRACT: Background/Objectives: Resveratrol (RSV) and curcumin (CRC) have antioxidant, anti-inflammatory, photoprotective, and cell-repairing properties. We selected them to investigate the potential role involved in human keratinocyte protection. Additionally, we tried to overcome the limitations of their application due to poor pharmacokinetics by introducing ferrocene into their structure. Methods: The multiple cellular endpoints-viability (determined by MTT and Trypan Blue method), ROS (reactive oxygen species) formation (evaluated by fluorescence intensity measurement), apoptosis and autophagy (assessed using flow cytometry) of trans-3,5,4'-tri(4-ferrocenylbutanoyloxy)-stilbene (RF) and (E)-5-(4-hydroxy-3-methoxyphenyl)-1-ferrocenylpent-4-ene-1,3-dione (CF), as well

SUBMITTER: Miletic M 

PROVIDER: S-EPMC12736313 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature