Acrylamide Determination in Infant Formulas: A New Extraction Method.

ABSTRACT: Infant formulas are specialized foods designed for babies and toddlers who cannot be exclusively breastfed. However, acrylamide (AA) may form during the thermal processing involved in their production. Although chromatographic techniques offer high sensitivity and detection capability for AA analysis, their application remains limited due to the complexity of diverse food matrices, high operating costs, time requirements, and environmental concerns. A new validated liquid chromatography-mass spectrometry (LC-MS) protocol for AA detection in infant formula was developed using sequential hydration, acetonitrile (ACN) precipitation, and dual-sorbent clean-up, which minimized matrix effects and ensured clarity and high reproducibility. The validated method demonstrated excellent linearity (R

SUBMITTER: Sevim S 

PROVIDER: S-EPMC12736327 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature