Practical utility of meropenem therapeutic drug monitoring: a systematic review of evidence for clinical application.

ABSTRACT:

Background and purpose

Therapeutic Drug Monitoring (TDM) is advocated to optimize antibiotic therapy, yet its efficacy remains debated. This systematic review and meta-analysis evaluates TDM's impact on meropenem therapy, focusing on treatment efficacy, bacterial clearance, and changes in biomarkers (C-reactive protein (CRP) levels, procalcitonin (PCT) levels, white blood cell (WBC) count, neutrophil ratios).

Methods

A systematic search was conducted across multiple databases, including PubMed, Embase, Web of Science, the Cochrane Library, and CNKI. Eligible studies comparing TDM with non-TDM approaches for meropenem were identified according to predefined inclusion and exclusion criteria. Pooled analyses were conducted using fixed-effects or random-effects models, selected

SUBMITTER: Zhao YC 

PROVIDER: S-EPMC12736388 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature