Microvesicles from Turmeric Extracts Contain Curcuminoids and Modulate Macrophage Polarization and Migration.

ABSTRACT: Background/Objectives: Recent studies have revealed that plants produce lipid-derived microvesicles with potent anti-inflammatory properties. In turmeric (Curcuma longa L.), such microvesicles have been identified in rhizome juice and shown to exert beneficial effects in murine models of colitis. In this study, we investigated whether turmeric extracts commonly used in phytotherapy (30% ethanolic or aqueous extracts, and freeze-dried or spray-dried preparations) contain Curcuma-derived microvesicles (CuMVs), and we evaluated the influence of extraction processes on their aggregation and morphology. Methods: All extracts were processed using a standardized protocol involving differential centrifugation, filtration, and ultracentrifugation. CuMVs with sizes from 50 to 20

SUBMITTER: Tacconi S 

PROVIDER: S-EPMC12736489 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature