N-arylsulfonyl hydrazones as inhibitors of IMP-1 metallo-beta-lactamase.

ABSTRACT: Members of a family of N-arylsulfonyl hydrazones have been identified as novel inhibitors of IMP-1, a metallo-beta-lactamase of increasing prevalence. Structure-activity relationship studies have indicated a requirement for bulky aromatic substituents on each side of the sulfonyl hydrazone backbone for these compounds to serve as efficient inhibitors of IMP-1. Molecular modeling has provided insight into the structural basis for the anti-metallo-beta-lactamase activity exhibited by this class of compounds.

SUBMITTER: Siemann S 

PROVIDER: S-EPMC127367 | biostudies-literature | 2002 Aug

REPOSITORIES: biostudies-literature