Co-Amorphous Systems Based on Dihydroquercetin and l-Lysine: Synthesis and Evaluation.

ABSTRACT: Background/Objectives: Dihydroquercetin (DHQ), also known as taxifolin, is a natural flavonoid which has anti-inflammatory and wound-healing biological effects. One of the main limitations for developing formulations with DHQ is its low solubility in water at room temperature. One of the high-potential co-formers for increasing its solubility is l-lysine, which has an aliphatic amino group in the side radical capable of entering into intermolecular interactions with the phenolic hydroxyl groups of DHQ. Methods: Several modifications were obtained using grinding, drying, and lyophilization methods. Subsequent evaluation was conducted using a combination of physicochemical and biological analytical methods. Results: Obtained modifications could be described as very easil

SUBMITTER: Svotin AA 

PROVIDER: S-EPMC12736791 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature