Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex.

ABSTRACT: Head direction (HD) signals function as the brain's internal compass. They are organized as an attractor and anchor to the environment via visual landmarks. Here, we examine how thalamic HD signals and visual information from the retrosplenial cortex combine in the presubiculum. We find that monosynaptic excitatory connections from anterior thalamic nucleus and from retrosplenial cortex converge on single layer 3 pyramidal neurons in the dorsal portion of mouse presubiculum. Independent dual-wavelength photostimulation of these inputs in slices leads to action potential generation preferentially for near-coincident inputs, indicating that layer 3 neurons can transmit a visually matched HD signal to medial entorhinal cortex. Layer 4 neurons, which innervate the lateral mammillary nucleus, f

SUBMITTER: Richevaux L 

PROVIDER: S-EPMC12736935 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature