Multifunctional Bilayer Wound Dressing Composed of Immediate Release Layer of Ofloxacin and Sustained Release Layer of Bergamot Oil.

ABSTRACT: Background: Wound healing is a typical biological process that the human body accomplishes through well-defined stages. The complexity of the healing process continues to be a significant health challenge. Multifunctional polymeric bilayer wound dressings have emerged as a new treatment option, as they resemble the bilayer structure of skin. Methods: Here, we developed a bilayer film with two distinct features, i.e., a primary sodium alginate (Na-Alg)-based sustained release layer incorporated with bergamot essential oil (BEO) and a secondary immediate release layer of hydroxypropyl methyl cellulose (HPMC) and hydroxyethyl cellulose (HEC) loaded with the antibacterial drug ofloxacin (OFX). Using the double solvent casting technique. Results: The resultant bilayer films

SUBMITTER: Nisa MU 

PROVIDER: S-EPMC12736944 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature