Surfactants Significantly Improved the Oral Bioavailability of Curcumin Amorphous Solid Dispersions and Its Underlying Mechanism.

ABSTRACT: Background/Objectives: Surfactants are commonly used in amorphous solid dispersions (ASDs) to improve drug dissolution. A mechanistic understanding of their impact on in vitro dissolution and in vivo pharmacokinetics is essential for rational ASD design and for establishing predictive in vitro-in vivo correlation (IVIVC). Methods: Binary (Cur/P188) and ternary (Cur/P188/TW80, Cur/P188/SLS) ASDs were prepared by rotary evaporation. Drug-polymer-surfactant interactions were characterized by ¹H NMR and FT-IR spectroscopy. To elucidate the bioavailability enhancement mechanism, we performed (i) in vitro non-sink dissolution to assess dissolution kinetics, nanostructure formation, and precipitate transformation; (ii) cellular uptake assays; and (iii) in vivo pharmacokin

SUBMITTER: Yuan J 

PROVIDER: S-EPMC12736958 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature