Insights into Missense SNPs on Amyloidogenic Proteins.

ABSTRACT: Background: Amyloidogenic proteins, a heterogenous group of proteins characterized by their ability to form amyloid fibrils, lead to pathological conditions when they undergo abnormal folding and self-assembly. Missense single-nucleotide polymorphisms (msSNPs) may occur in their sequence, disrupting the normal structure and function of these proteins, pushing them towards amyloidogenesis. Methods: A comprehensive dataset of amyloidogenic proteins was created and their msSNPs were collected and mapped on their amino acid sequence. The chi squared test, logistic regression and the bootstrap method were used to ascertain the statistical significance of the results. Results: The distribution of pathogenic and benign msSNPs highlighted the predicted amyloidogenic segments a

SUBMITTER: Galanis FP 

PROVIDER: S-EPMC12736960 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature