Longitudinal Health Risk Assessment of Neonicotinoid Exposure and Its Association with Dietary Sources in School-Aged Children: A Prospective Cohort Study.

ABSTRACT: Neonicotinoid insecticides (NNIs) are globally pervasive, and toxicological evidence indicates potential adverse effects from low-dose exposure in non-targeted organisms. Humans may be exposed to NNIs through multiple pathways, such as ingestion and inhalation, with dietary intake recognized as the dominant exposure route. However, longitudinal evidence characterizing evolving exposure patterns in rural children remains scarce. We evaluated temporal trends and dietary determinants of NNI exposure among 643 children at ages 7, 10, and 14 years in the Sheyang Mini Birth Cohort Study. Twelve NNIs and six metabolites in urine samples were measured using UPLC-HRMS; estimated daily exposure doses and hazard index (HI) were calculated, and linear mixed models were used to evaluate dietary determi

SUBMITTER: Zhang B 

PROVIDER: S-EPMC12737067 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature