Assessing Perfluorooctane Sulfonate (PFOS) Toxicity and Carcinogenicity Through Zebrafish (<i>Danio rerio</i>) Xenograft Assays.

ABSTRACT: Persistent environmental pollutants such as per- and poly-fluoroalkyl substances (PFAS) have been associated with a wide range of toxic effects, including cancer. There are over 12,000 PFAS compounds, which may act as carcinogens individually or in combinations. Therefore, efficient in vivo new approach models of carcinogenicity are needed for evaluating environmental contaminant compounds and chemical mixtures. Here, we use the larval zebrafish xenograft assay to identify tumor growth activity of perfluorooctane sulfonate (PFOS), a known carcinogenic PFAS. Dose-response curves for PFOS exposure were used to identify the Maximum Tolerated Concentration (MTC) and Lethal Concentration causing 50% death (LC₅₀) under xenograft conditions. Zebrafish xenografts were established by inj

SUBMITTER: Block T 

PROVIDER: S-EPMC12737301 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature