Differential Effects of Marimastat and Prinomastat on the Metalloprotease Activity of Various Snake Venoms.

ABSTRACT: Snakebite envenoming is a neglected tropical disease, responsible for approximately 140,000 deaths globally each year. Vipers and elapid snakes represent the most significant snake families in medical contexts, exhibiting a variety of venom components and clinical effects in bite victims. Metalloproteases, a primary component of venoms, are mainly accountable for haemotoxic and myotoxic effects. Although predominantly found in viper venoms, these enzymes are also present in varying levels in elapid snake venoms. Marimastat and prinomastat are matrix metalloprotease inhibitors initially developed as cancer therapies. Recently, extensive research has focused on these inhibitors to neutralise venom metalloproteases. However, their effects on different viper and elapid snake venoms remain uncl

SUBMITTER: Khatibi M 

PROVIDER: S-EPMC12737354 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature