Antibiotic Exposure in School Children in Tropical Environments: Impact of Dietary Habits and Potential Health Risks.

ABSTRACT: Due to their wide application, there is a large amount of residual antibiotics in our environment and food, raising concerns about health risks to children. In this study, 302 primary-school students in Hainan Province, China, were recruited to collect urine samples and questionnaires. The internal exposure levels of sixteen antibiotics and three metabolites in urine were determined by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), and the contents of DNA oxidative damage markers, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and lipid peroxidation marker malondialdehyde (MDA), were also measured. Antibiotics and their metabolites were frequently detected, with a total concentration of < LOD-4.58 × 10³ ng/mL. Binary logistic regression analysis revealed tha

SUBMITTER: Zhao L 

PROVIDER: S-EPMC12737428 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature