Identification of the Role of <i>NAT10</i> in the Regulation of Porcine Circovirus Type 2 Infection.

ABSTRACT: Porcine circovirus type 2 (PCV2) represents a principal infectious agent causing considerable economic detriment to swine production. N-acetyltransferase 10 (NAT10), which catalyzes N⁴-acetylcytidine (ac⁴C) deposition, has been implicated in regulating immune responses, RNA stability, and viral replication. However, its role in PCV2 infection remains unclear. In this study, we established a PCV2-infected PK15 cell model and observed a marked downregulation of NAT10 expression following infection. Functional assays demonstrated that NAT10 knockdown significantly suppressed PCV2 replication in PK15 cells. Comparative transcriptomic analysis revealed that NAT10 silencing altered the expression of 81 genes, predominantly involved in immune-related signaling pathways. Nota

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12737480 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature