Beta Toxins Isolated from the Scorpion <i>Centruroides hirsutipalpus</i> (Scorpiones; Buthidae) Affect the Function of Sodium Channels of Mammals.

ABSTRACT: Scorpion venom toxins are important peptides being studied for their clinical significance. These peptides act by binding to ion channels in the membrane of nerve cells, causing the symptoms associated with scorpion stings (scorpionism). They principally affect the function of voltage-gated sodium channels (Nav) and are valuable for studying ion channels. Scorpions from the Buthidae family contain toxins that affect sodium channels and have a high affinity for mammalian channels. In this study, two sodium toxins isolated from the venom of the scorpion Centruroides hirsutipalpus, a member of the Buthidae family, were identified as belonging to the beta-type subfamily. These toxins were purified from whole venom using molecular exclusion, cationic-exchange, and reverse-phase chromatog

SUBMITTER: Valdez-Velazquez LL 

PROVIDER: S-EPMC12737490 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature