Dose-Response Evaluation of Sugammadex for Reversal of Deep Rocuronium-Induced Neuromuscular Block in Cats.

ABSTRACT: Background: Sugammadex is a selective γ-cyclodextrin compound that encapsulates steroidal neuromuscular blocking agents such as rocuronium, allowing rapid and predictable recovery from neuromuscular block (NMB). However, dose-response information in feline patients remains limited. Methods: In this prospective, randomized, and blinded experimental study, three intravenous doses of sugammadex (2, 4, and 8 mg kg^-1) were compared for the reversal of profound rocuronium-induced NMB (0.6 mg kg^-1) in thirty adult ASA I cats anesthetized with sevoflurane. Neuromuscular function was continuously assessed using acceleromyography (train-of-four stimulation). The onset and recovery times for T₁/T₀ ratios of 25-90%, T₄/T₁

SUBMITTER: Cesnik NM 

PROVIDER: S-EPMC12737506 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature